Which European city has the highest ketamine use in wastewater testing?

Sunlight reflecting on the water of the Floating Harbour in Bristol, England, beside red-brick buildings

Bristol, England, recorded the highest ketamine level of any European city in the latest Europe-wide wastewater study. Its 2025 sampling week averaged 338.95 milligrams of ketamine per 1,000 people per day, more than double the next European city, Amsterdam (149.33 mg), followed by Berlin (132.23 mg). Bristol’s highest single day was a Saturday, at 551.57 … Read more

What is ARO-MAPT, and how much did it lower tau in early testing?

Illustration comparing a healthy neuron with stable microtubules and a diseased neuron where tau proteins form tangled clumps

ARO-MAPT is an experimental RNA interference (RNAi) drug from Arrowhead Pharmaceuticals, given as an injection under the skin, that is designed to silence the MAPT gene in the brain and so reduce production of tau, a protein that clumps into tangles in Alzheimer’s disease and related disorders called tauopathies. In interim Phase 1/2a results announced … Read more

What is a Roth IRA conversion?

Glass savings jar filled with coins and a folded banknote

A Roth IRA conversion moves money from a traditional, SEP, or SIMPLE IRA into a Roth IRA. Untaxed amounts are taxed as income in the year you convert, there is no income limit, it is reported on Form 8606, and since 2018 it cannot be reversed.